The Biotinylated Anti-CD40 Antibody (HDLA062) is a powerful tool for researchers studying CD40, a cell surface receptor involved in immune responses and B cell activation. This antibody, produced using state-of-the-art technology, has been specifically designed to detect CD40 protein in various cell types, making it ideal for studies in immunology, oncology, and autoimmune diseases.By binding to the CD40 protein, this antibody enables precise detection and analysis of CD40 expression levels in cells, tissues, and biological samples. Its high specificity and sensitivity allow for accurate quantification and visualization of CD40, facilitating research on the role of this receptor in immune regulation and disease pathogenesis.
The Biotinylated Anti-CD40 Antibody (HDLA062) is validated for use in various applications, including Western blotting, immunohistochemistry, and flow cytometry, providing researchers with versatile options for investigating CD40 function and behavior. With its reliable performance and reproducibility, this antibody is a valuable tool for advancing scientific understanding and discovering novel therapeutic targets related to CD40 signaling pathways.
SKU:
HDLA062
Size:
100 µg
Clonality:
Monoclonal
Clone:
DM100
Synonyms:
CD40, Bp50, CDW40, MGC9013, TNFRSF5, p50
Applications:
ELISA, Flow Cyt
Recommended Dilution:
ELISA 1:5000-10000; Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit IgG
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
