The Biotinylated Anti-GITR Antibody (HDLA042) is a valuable tool for researchers studying GITR, a member of the tumor necrosis factor receptor superfamily that plays a key role in regulating immune responses. This antibody, developed for use in various applications, including Western blot and immunohistochemistry, is highly specific for GITR and demonstrates strong reactivity with human samples.GITR, also known as glucocorticoid-induced TNFR-related protein, is a promising target for immunotherapy due to its ability to modulate T cell responses and promote anti-tumor immunity.
Research on GITR has revealed its potential in enhancing immune responses against cancer and autoimmune diseases. The Biotinylated Anti-GITR Antibody (HDLA042) allows for the precise detection and analysis of GITR expression, making it a valuable tool for investigating the role of GITR in immune regulation and disease pathogenesis.
SKU:
HDLA042
Size:
100 µg
Clonality:
Monoclonal
Clone:
DM80
Synonyms:
AITR, GITR, TNFRSF18, CD357
Applications:
ELISA, Flow Cyt
Recommended Dilution:
ELISA 1:5000-10000; Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit IgG
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25( )CD4( ) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
