The BMPR2 Antibody (CAB5666) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the BMPR2 protein, this antibody allows for the detection and analysis of BMPR2 expression in various cell types.The BMP signaling pathway is involved in a wide range of biological processes, including cell growth, differentiation, and apoptosis. Dysregulation of this pathway, particularly through mutations in BMPR2, has been linked to various diseases, including pulmonary arterial hypertension and hereditary hemorrhagic telangiectasia.
This antibody is validated for use in WB, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
BMPR2 Antibody
SKU:
CAB5666
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Cell Membrane, Single-Pass Type I Membrane Protein.
Calculated MW:
115kDa
Observed MW:
100kDa
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.
Purification Method
Affinity purification
Gene ID
659
RRID
AB_2766426
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates, using BMPR2 Rabbit pAb (CAB5666) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 20s.
Immunofluorescence analysis of U-2OS cells using BMPR2 Rabbit pAb (CAB5666) at dilution of 1:100. Blue: DAPI for nuclear staining.
