C4A Rabbit Polyclonal Antibody (CAB9511)
- SKU:
- CAB9511
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
Product Name: | C4A Rabbit Polyclonal Antibody |
SKU: | CAB9511 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1200-1446 of human Complement C4A (NP_009224.2). |
Sequence: | LTLT KAPV DLLG VAHN NLMA MAQE TGDN LYWG SVTG SQSN AVSP TPAP RNPS DPMP QAPA LWIE TTAY ALLH LLLH EGKA EMAD QASA WLTR QGSF QGGF RSTQ DTVI ALDA LSAY WIAS HTTE ERGL NVTL SSTG RNGF KSHA LQLN NRQI RGLE EELQ FSLG SKIN VKVG GNSK GTLK VLRT YNVL DMKN TTCQ DLQI EVTV KGHV EYTM EANE DYED YEYD ELPA KDDP DAPL QPVT PLQL FEG |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | C4; RG; C4S; CO4; C4A2; C4A3; C4A4; C4A6; C4AD; CPAMD2; Complement C4A |
Positive Sample: | HepG2 |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted. |
Calculated MW: | 193kDa |
Observed MW: | 192kDa |
This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain is cleaved to release C4 anaphylatoxin, an antimicrobial peptide and a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 720 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |