Calreticulin Antibody is a rabbit polyclonal antibody directed against Calreticulin, offered by Assay Genie for research applications. Reported applications include WB, IHC, ICC/IF, IP and FCM. Reported reactivity: Human, Mouse, Rat, Bovine, Dog, Chicken, Guinea Pig (Cavia porcellus), Monkey, Pig, Hamster, Rabbit and Sheep. Purified by Peptide Affinity.
Calreticulin (CALR) is a highly conserved, multifunctional calcium-binding protein predominantly localized to the endoplasmic reticulum (ER), but also detected in the nucleus and nuclear envelope. It contains a C-terminal KDEL sequence that ensures ER retention, a hallmark of many ER-resident chaperones. Structurally, Calreticulin comprises three domains: a 180-residue N-terminal domain, a proline-rich P-domain (residues 189–288) with high-affinity calcium-binding capacity and homology to calnexin and calmegin, and a C-terminal domain that binds calcium with low affinity but high capacity. This architecture enables Calreticulin to function as both a calcium buffer and a molecular chaperone. In the nervous system, Calreticulin plays a critical role in protein folding, calcium signaling, and ER stress responses—processes intimately linked to neurodegenerative disease. It assists in the maturation of glycoproteins and regulates intracellular calcium dynamics, which are essential for synaptic function and neuronal survival. Dysregulation of Calreticulin has been implicated in neurodegenerative conditions such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS), where ER stress and disrupted proteostasis are central pathological features. Beyond its chaperone role, Calreticulin influences gene expression, cytoskeletal organization, and cellular proliferation. It is also upregulated in response to various stressors, including amino acid deprivation, highlighting its role in adaptive cellular responses. Given its central position at the intersection of calcium homeostasis, protein quality control, and stress signaling, Calreticulin is a promising target in neurodegenerative disease research. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 200 µl. For research use only; not for diagnostic or therapeutic procedures.
Product Name:
Calreticulin Antibody
Product SKU:
STPA00017
Size:
200 µl
Target:
Calreticulin
Host Species:
Rabbit
Antibody Type:
Polyclonal
Research Areas:
Cell Signaling, Protein Trafficking, Organelle Proteins, Tags and Cell Markers, Organelle Markers
Buffer:
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage & Shipping:
Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
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