Caplacizumab Antibody is a research-grade biosimilar monoclonal antibody targeting von Willebrand antigen II. Format: VH-VH (humanized host). Reactivity: Human. Supplied as a liquid in 20 mM citric acid, 6.2% sucrose, 0.01% Tween80. Applications: ELISA, flow cytometry, functional assays and in vivo research. Endotoxin: < 10 EU/mg. Purity: >95% purity as determined by SDS-PAGE. For research use only.
von Willebrand factor (VWF) is a ~309 kDa protein. Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
