The CARD8 Antibody (CAB0293) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the CARD8 protein, researchers can accurately detect and analyze its expression in various cell types, making it a key player in immunological and cancer research.CARD8, also known as TUCAN (Tumor necrosis factor (TNF) alpha-induced protein 3), is a crucial component in the regulation of immune responses and inflammation.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.
Product Name:
CARD8 Antibody
SKU:
CAB0293
Size:
20μL, 100μL
Reactivity:
Human
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
NDPP, DACAR, DAKAR, NDPP1, TUCAN, CARDINAL, CARD8
Positive Sample:
K-562, A673, ES-2
Cellular Localization:
Cytoplasm, Nucleus.
Calculated MW:
61kDa
Observed MW:
60kDa
The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene.
Purification Method
Affinity purification
Gene ID
22900
RRID
AB_2757105
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
