| UniProt Protein Function: | CCL4L1: Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5. Belongs to the intercrine beta (chemokine CC) family. 10 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Chemokine; Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 17q12 |
| NCBI Summary: | This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this family member is similar to the chemokine (C-C motif) ligand 4 product, which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals, where most individuals have one to five copies. This gene copy contains a non-consensus splice acceptor site at the 3' terminal exon found in other highly similar gene copies, and it thus uses other alternative splice sites for the 3' terminal exon, resulting in multiple transcript variants. [provided by RefSeq, Apr 2014] |
| UniProt Code: | Q8NHW4 |
| NCBI GenInfo Identifier: | 74727347 |
| NCBI Gene ID: | 9560 |
| NCBI Accession: | Q8NHW4.1 |
| UniProt Secondary Accession: | Q8NHW4,Q50EM1, Q50EM2, Q50EM3, Q50EM4, Q50EM5, Q50EM6 Q50EM7, Q50EM8, Q569J2, B2RUZ3, B7ZMA8, |
| Molecular Weight: | 11,008 Da |
| NCBI Full Name: | C-C motif chemokine 4-like |
| NCBI Synonym Full Names: | chemokine (C-C motif) ligand 4-like 2 |
| NCBI Official Symbol: | CCL4L2Â Â |
| NCBI Official Synonym Symbols: | CCL4L; SCYA4L; AT744.2; SCYQ4L2Â Â |
| NCBI Protein Information: | C-C motif chemokine 4-like |
| UniProt Protein Name: | C-C motif chemokine 4-like |
| UniProt Synonym Protein Names: | Lymphocyte activation gene 1 protein; LAG-1; Macrophage inflammatory protein 1-beta; MIP-1-beta; Monocyte adherence-induced protein 5-alpha; Small-inducible cytokine A4-like |
| Protein Family: | C-C motif chemokine |
| UniProt Gene Name: | CCL4L1Â Â |
| UniProt Entry Name: | CC4L_HUMAN |
