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CD163 monoclonal antibody (AGIM0091)

SKU:
AGIM0091
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
GHI/61
Conjugation:
Unconjugated
Applications:
FC
€179
Frequently bought together:

Description

system_update_altDatasheet
Product Name:CD163 monoclonal antibody
Product Code:AGIM0091
Size:100 µg in 100 µL
Reactivity:Human
Clone:GHI/61
Applications:Flow Cytometry
Conjugate:Unconjugated
Isotype:IgG1
Host Species:Mouse
Storage:Store at 2 °- 8°C. Do not freeze!
Uniprot:Q86VB7
Background:CD163, also known as M130, is a member of the scavenger receptor family, accounting for the clearance of hemoglobin-haptoglobin complexes during limited hemolysis, which protects the body, in particular the kidneys, against heme-mediated oxidative damages. It does not have measurable affinity for noncomplexed hemoglobin or haptoglobin. Immunomodulatory role of CD163 has been postulated. CD163 is expressed by cells of the monocyte-macrophage lineage and its extracellular part also circulates in plasma as a soluble protein, especially during sepsis and other conditions affecting macrophage activity, when its level may raise manyfold.
NCBI Summary:The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
UniProt Code:Q86VB7
NCBI GenInfo Identifier:313104083
NCBI Gene ID:9332
NCBI Accession:
UniProt Related Accession:Q86VB7
Molecular Weight:
NCBI Full Name:Scavenger receptor cysteine-rich type 1 protein M130
NCBI Synonym Full Names:CD163 molecule
NCBI Official Symbol:CD163  
NCBI Official Synonym Symbols:M130; MM130; SCARI1  
NCBI Protein Information:scavenger receptor cysteine-rich type 1 protein M130
UniProt Protein Name:
Protein Family:Scavenger receptor cysteine-rich type 1 protein
UniProt Gene Name:

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