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CD18 monoclonal antibody (FITC) (AGIM0312)

SKU:
AGIM0312
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
HI18a
Conjugation:
FITC
Applications:
FC
€179
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Description

system_update_altDatasheet
Product Name:CD18 monoclonal antibody (FITC)
Product Code:AGIM0312
Size:100 µL
Reactivity:Human
Clone:HI18a
Applications:Flow Cytometry
Conjugate:FITC
Isotype:IgG1
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot: P05107 
Background:CD18, integrin ??2 subunit, forms heterodimers with four types of CD11 molecule to constitute leukocyte (??2) integrins: ?±L??2 (CD11a/CD18, LFA-1), ?±M??2 (CD11b/CD18, Mac-1, CR3), ?±X??2 (CD11c/CD18) and ?±D??2 (CD11d/CD18). In most cases, the response mediated by the integrin is a composite of the functions of its individual subunits. These integrins are essential for proper leukocyte migration, mediating intercellular contacts. Absence of CD18 leads to leukocyte adhesion deficiency-1; severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediated cytolysis.

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