Anti-CD3G Antibody (CAB1938)

Antibody Name:	Anti-CD3G Antibody
Antibody SKU:	CAB1938
Antibody Size:	20uL, 100uL
Application:	WB
Reactivity:	Human
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 23-116 of human CD3G (NP_000064.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human
Positive Samples:

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 23-116 of human CD3G (NP_000064.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	QSIK GNHL VKVY DYQE DGSV LLTC DAEA KNIT WFKD GKMI GFLT EDKK KWNL GSNA KDPR GMYQ CKGS QNKS KPLQ VYYR MCQN CIEL NAAT IS
Gene ID:	917
Uniprot:	P09693
Cellular Location:	Membrane, Single-pass type I membrane protein
Calculated MW:	20kDa
Observed MW:	Refer to figures

Synonyms:

CD3G, CD3-GAMMA, IMD17, T3G

Background:

The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency.

UniProt Protein Function:	Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface (PubMed:8187769). Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G.
NCBI Summary:	The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008]
UniProt Code:	P09693
NCBI GenInfo Identifier:	115993
NCBI Gene ID:	917
NCBI Accession:	P09693.1
UniProt Secondary Accession:	P09693,Q2HIZ6,
UniProt Related Accession:	P09693
Molecular Weight:	20,469 Da
NCBI Full Name:	T-cell surface glycoprotein CD3 gamma chain
NCBI Synonym Full Names:	CD3g molecule
NCBI Official Symbol:	CD3G
NCBI Official Synonym Symbols:	T3G; IMD17; CD3-GAMMA
NCBI Protein Information:	T-cell surface glycoprotein CD3 gamma chain
UniProt Protein Name:	T-cell surface glycoprotein CD3 gamma chain
UniProt Synonym Protein Names:	T-cell receptor T3 gamma chain; CD_antigen: CD3g
Protein Family:	T-cell surface glycoprotein
UniProt Gene Name:	CD3G

Antibodies

CD3G Antibody (PACO08288)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)