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CD49d monoclonal antibody (APC) (AGIM0476)

SKU:
AGIM0476
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rat
Isotype:
IgG2b
Clone:
PS/2
Conjugation:
APC
Applications:
FC
€179
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Description

system_update_altDatasheet
Product Name:CD49d monoclonal antibody (APC)
Product Code:AGIM0476
Size:100 µL
Reactivity:Human
Clone:PS/2
Applications:Flow Cytometry
Conjugate:APC
Isotype:IgG2b
Host Species:Rat
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:Q00651
Background:Integrins alpha-4/beta-1 (VLA-4 or LPAM-2) and alpha-4/beta-7 (LPAM-1) are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. Integrin alpha4/beta-7 is also a receptor for MADCAM1. Mice homozygous for a null mutation of the alpha-4 subunit gene die by day E11-E14 from detachment and rupture of the epicardium and coronary arteries.
UniProt Code:Q00651
NCBI GenInfo Identifier:114326554
NCBI Gene ID:16401
NCBI Accession:NP_034706.3
UniProt Related Accession:Q00651
Molecular Weight:115,696 Da
NCBI Full Name:integrin alpha-4
NCBI Synonym Full Names:integrin alpha 4
NCBI Official Symbol:Itga4  
NCBI Official Synonym Symbols:CD49D; Itga4B  
NCBI Protein Information:integrin alpha-4; CD49 antigen-like family member D; LPAM subunit alpha; VLA-4 receptor, alpha 4 subunit; VLA-4 subunit alpha; integrin alpha-IV; integrin alpha4B; lymphocyte Peyer patch adhesion molecules subunit alpha
UniProt Protein Name:Integrin alpha-4
UniProt Synonym Protein Names:CD49 antigen-like family member D; Integrin alpha-IV; Lymphocyte Peyer patch adhesion molecules subunit alpha; LPAM subunit alpha; VLA-4 subunit alpha; CD_antigen: CD49d
UniProt Gene Name:Itga4  
UniProt Entry Name:ITA4_MOUSE

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