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CD54 monoclonal antibody (AGIM0050)

SKU:
AGIM0050
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a
Clone:
MEM-111
Conjugation:
Unconjugated
Applications:
FC
€179
Frequently bought together:

Description

system_update_altDatasheet
Product Name:CD54 monoclonal antibody
Product Code:AGIM0050
Size:100 µg in 100 µL
Reactivity:Human, Rat, Bovine
Clone:MEM-111
Applications:Flow Cytometry
Conjugate:Unconjugated
Isotype:IgG2a
Host Species:Mouse
Storage:Store at 4°C. For long-term storage aliquot and store at -20°C. Avoid freeze/thaw cycles.
Uniprot:P05362
Background:CD54 (ICAM-1) is a 90 kD member of the C2 subset of immunoglobulin superfamily. It is a transmembrane molecule with 7 potential N-glycosylated sites, expressed on resting monocytes and endothelial cells and can be upregulated on many other cells, e.g. with lymphokines, on B- and T-lymphocytes, thymocytes, dendritic cells and also on keratinocytes, chondrocytes, as well as epithelial cells. CD54 mediates cell adhesion by binding to integrins CD11a/CD18 (LFA-1) and to CD11b/CD18 (Mac-1). The interaction of CD54 with LFA-1 enhances antigen-specific T-cell activation.
UniProt Protein Function:ICAM1: a type I membrane protein of the immunoglobulin superfamily. Is a ligand for the leukocyte adhesion LFA-1 protein (Integrin alpha-L/beta-2) and a Rhinovirus receptor. Typically expressed on endothelial cells and cells of the immune system. ICAM1 binds to integrins of type CD11a / CD18, or CD11b / CD18. Its expression is activated by p53 in an NF-kappaB-independent manner. Induced by TNFalpha in a process that involves IKKbeta.
UniProt Protein Details:

Protein type:Immunoglobulin superfamily; Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 19p13.3-p13.2

Cellular Component: extracellular space; focal adhesion; cell surface; membrane; integral to plasma membrane; plasma membrane; immunological synapse; external side of plasma membrane

Molecular Function:viral receptor activity; integrin binding; protein binding; transmembrane receptor activity; receptor activity

Biological Process: entry of virus into host cell; extracellular matrix organization and biogenesis; positive regulation of nitric oxide biosynthetic process; T cell antigen processing and presentation; response to organic cyclic substance; activation of NF-kappaB transcription factor; positive regulation of cellular extravasation; regulation of cell shape; leukocyte adhesion; cellular response to nutrient levels; sensory perception of sound; ovarian follicle development; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; membrane to membrane docking; response to sulfur dioxide; cell adhesion; regulation of leukocyte mediated cytotoxicity; acute inflammatory response to antigenic stimulus; response to drug; regulation of cell adhesion; virion attachment, binding of host cell surface receptor; negative regulation of calcium ion transport; regulation of immune response; cytokine and chemokine mediated signaling pathway; response to amphetamine; cell aging; response to amino acid stimulus; heterophilic cell adhesion; positive regulation of peptidyl-tyrosine phosphorylation; response to ethanol; response to copper ion; positive regulation of actin filament polymerization; positive regulation of vasoconstriction; adhesion to host; cell adhesion mediated by integrin; response to ionizing radiation; leukocyte migration

Disease: Malaria, Susceptibility To

NCBI Summary:This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]
UniProt Code:P05362
NCBI GenInfo Identifier:68067956
NCBI Gene ID:3383
NCBI Accession:P05362.2
UniProt Secondary Accession:P05362,Q5NKV7, Q96B50, B2R6M3,
UniProt Related Accession:P05362
Molecular Weight:
NCBI Full Name:Intercellular adhesion molecule 1
NCBI Synonym Full Names:intercellular adhesion molecule 1
NCBI Official Symbol:ICAM1  
NCBI Official Synonym Symbols:BB2; CD54; P3.58  
NCBI Protein Information:intercellular adhesion molecule 1; ICAM-1; cell surface glycoprotein P3.58; major group rhinovirus receptor; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
UniProt Protein Name:Intercellular adhesion molecule 1
UniProt Synonym Protein Names:Major group rhinovirus receptor; CD_antigen: CD54
Protein Family:Intercellular adhesion molecule
UniProt Gene Name:ICAM1  
UniProt Entry Name:ICAM1_HUMAN

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