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CD58 monoclonal antibody (FITC) (AGIM0052)

SKU:
AGIM0052
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
MEM-63
Conjugation:
FITC
Applications:
FC
€179
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Description

system_update_altDatasheet
Product Name:CD58 monoclonal antibody (FITC)
Product Code:AGIM0052
Size:500 µL
Reactivity:Human, Porcine
Clone:MEM-63
Applications:Flow Cytometry
Conjugate:FITC
Isotype:IgG1
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:P19256
Background:CD58 (LFA-3) is an immunoglobulin family adhession molecule expressed by both hematopoietic and non-hematopoietic cells (often on antigen presenting cells) and serving as ligand of CD2. This interaction is important for T cell-mediated immunity. CD58 is expressed in transmembrane form and in GPI-anchored form; the later is constitutively associated with protein kinases whereas the transmembrane form activates kinase activity upon triggering. CD58 is a powerful tool for detection of minimal residual disease in acute lymphocytic leukemia, and for evaluation of liver damage related with hepatitis B.
UniProt Protein Function:Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells.
NCBI Summary:This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. The protein is localized to the plasma membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]
UniProt Code:P19256
NCBI GenInfo Identifier:126225
NCBI Gene ID:965
NCBI Accession:P19256.1
UniProt Secondary Accession:P19256,Q5U053, Q6IB65, Q96KI9, A8K7G5,
UniProt Related Accession:P19256
Molecular Weight:27,960 Da
NCBI Full Name:Lymphocyte function-associated antigen 3
NCBI Synonym Full Names:CD58 molecule
NCBI Official Symbol:CD58  
NCBI Official Synonym Symbols:ag3; LFA3; LFA-3  
NCBI Protein Information:lymphocyte function-associated antigen 3
UniProt Protein Name:Lymphocyte function-associated antigen 3
UniProt Synonym Protein Names:Surface glycoprotein LFA-3; CD_antigen: CD58
Protein Family:Lymphocyte function-associated antigen
UniProt Gene Name:CD58  

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