Anti-CD62E (no azide) Antibody (AGIM0139)

CD62E (no azide) monoclonal antibody (AGIM0139)

SKU:

AGIM0139

Product Type:

Antibody

Antibody Type:

Monoclonal Antibody

Reactivity:

Human

Host Species:

Mouse

Isotype:

IgG1

Clone:

hCD62E

Conjugation:

Unconjugated

Applications:

Description

Description

Datasheet

Isotype:	IgG1
Host Species:	Mouse
Storage:	Aliquot and store at -20°C. Avoid freeze/thaw cycles. Should be handled under asepticconditions.
Uniprot:	P16581
Background:	The Selectin family is comprised of three members, E-Selectin, L-Selectin, and P-Selectin. ESelectin (CD62E) is transiently expressed on vascular endothelial cells in response to IL-1 beta and TNFalpha. L-Selectin (CD62L) is expressed constitutively on a wide variety of leukocytes. Two forms of LSelectin have been reported, apparently arising as a result of post-translational modifications. Human PSelectin (CD62P) is expressed by activated platelets and endothelial cells. This material is offered for research only. Not for use in human. For in vitro use only. ImmunoTools will not be held responsible for patent infringement or other violations that may occur with the use of our products. .

UniProt Protein Function:	SELE: Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis. Belongs to the selectin/LECAM family.
UniProt Protein Details:	Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 1q22-q25 Cellular Component: cortical cytoskeleton; extracellular space; perinuclear region of cytoplasm; plasma membrane; integral to membrane; coated pit; caveola; lipid raft Molecular Function:protein binding; transmembrane receptor activity; phospholipase binding; sialic acid binding Biological Process: positive regulation of leukocyte migration; positive regulation of receptor internalization; actin filament-based process; calcium-mediated signaling; response to lipopolysaccharide; leukocyte migration during inflammatory response; heterophilic cell adhesion; leukocyte adhesion; phospholipase C activation; regulation of inflammatory response; blood coagulation; inflammatory response; leukocyte tethering or rolling; leukocyte migration Disease: Hypertension, Essential
NCBI Summary:	The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008]
UniProt Code:	P16581
NCBI GenInfo Identifier:	126180
NCBI Gene ID:	6401
NCBI Accession:	P16581.1
UniProt Secondary Accession:	P16581,P16111, A2RRD6,
UniProt Related Accession:	P16581
Molecular Weight:	66,655 Da
NCBI Full Name:	E-selectin
NCBI Synonym Full Names:	selectin E
NCBI Official Symbol:	SELE
NCBI Official Synonym Symbols:	ELAM; ESEL; CD62E; ELAM1; LECAM2
NCBI Protein Information:	E-selectin; ELAM-1; endothelial adhesion molecule 1; CD62 antigen-like family member E; endothelial leukocyte adhesion molecule 1; leukocyte endothelial cell adhesion molecule 2; leukocyte-endothelial cell adhesion molecule 2
UniProt Protein Name:	E-selectin
UniProt Synonym Protein Names:	CD62 antigen-like family member E; Endothelial leukocyte adhesion molecule 1; ELAM-1; Leukocyte-endothelial cell adhesion molecule 2; LECAM2; CD_antigen: CD62E
Protein Family:	E-selectin
UniProt Gene Name:	SELE
UniProt Entry Name:	LYAM2_HUMAN