Description
Chicken IL10 Recombinant Protein (C-Strep)
Chicken IL10 Recombinant Protein (C-Strep) is a recombinant protein expressed in mammalian cells, spanning Leu22-Arg174, with a C-terminal Strep tag. Predicted molecular weight: 21.30 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Interleukin-10 is a ~20 kDa protein. Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. For research use only.
Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF. Also interferes with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation.
| Product Name: | Chicken IL10 Recombinant Protein (C-Strep) |
| SKU: | GXRP10735 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Chicken |
| Synonyms: | CSIF, Cytokine synthesis inhibitory factor, IL-10, IL10, Interleukin-10 |
| Tag: | C-Strep |
| Expression Host: | Mammalian cells |
| Protein Length: | Leu22-Arg174 |
| Calculated MW: | 21.30 kDa |
| UniProt: | Q6A2H4 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
