The CHUK Polyclonal Antibody (CAB0422) is a specialized antibody designed for research studies involving the CHUK protein, also known as Inhibitor of nuclear factor kappa-B kinase subunit alpha. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for Western blot applications.CHUK is a key player in the regulation of the NF-kappa B signaling pathway, which is implicated in a variety of cellular processes including immune response, inflammation, and cell survival. The CHUK Polyclonal Antibody enables specific detection and analysis of the CHUK protein in a variety of cell types, making it an invaluable tool for researchers studying immune regulation, inflammatory diseases, and cancer.
Understanding the role of CHUK in NF-kappa B signaling is essential for unraveling its potential therapeutic implications in conditions such as autoimmune disorders, inflammatory diseases, and cancer. The CHUK Polyclonal Antibody provides researchers with a reliable and accurate means of studying CHUK protein expression and function, driving forward advancements in the field of immunology and oncology research.
Product Name:
IKKα Rabbit Polyclonal Antibody
SKU:
CAB0422
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 600-700 of human IKKα (NP_001269.3).
This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor.
Purification Method:
Affinity purification
Gene ID:
1147
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using IKKα Rabbit pAb (CAB0422) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
