The CIAO2A Polyclonal Antibody (PACO41078) is a crucial tool for researchers studying CIAO2A, a protein involved in various cellular processes such as inflammation and immune response regulation. This antibody is specifically designed to target CIAO2A in human samples and has been validated for use in Western blot applications. Raised in rabbits, this highly reactive antibody binds to CIAO2A protein, allowing for accurate detection and analysis in a variety of cell types. Its versatility makes it ideal for use in studies related to immunology, cancer research, and inflammatory conditions.
CIAO2A's role in modulating immune responses and inflammation underscores its importance as a potential therapeutic target for diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. By understanding how CIAO2A functions, researchers can develop targeted therapies that manipulate immune function to combat these diseases effectively. Overall, the CIAO2A Polyclonal Antibody (PACO41078) is a valuable tool for researchers seeking to unravel the complex mechanisms underlying immune regulation and develop innovative treatments for a range of diseases.
Antibody Name:
CIAO2A Antibody (PACO41078)
Antibody SKU:
PACO41078
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:2000
Species Reactivity:
Human, Mouse
Immunogen:
Recombinant Human Cytosolic iron-sulfur assembly component 2A protein (1-160AA)
Western blot. All lanes: CIAO2A antibody at 8µg/ml + NIH/3T3 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 19, 12 kDa. Observed band size: 19 kDa.
Background:
Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component and in collaboration with CIAO1 specifically matures ACO1 and stabilizes IREB2, connecting cytosolic iron-sulfur protein maturation with cellular iron regulation. May play a role in chromosome segregation through establishment of sister chromatid cohesion. May induce apoptosis in collaboration with APAF1
Synonyms:
Cytosolic iron-sulfur assembly component 2A, MIP18 family protein FAM96A, CIAO2A, CIA2A, FAM96A
UniProt Protein Function:
FAM96A: May play a role in chromosome segregation through establishment of sister chromatid cohesion. Belongs to the MIP18 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 15q22.31Cellular Component: nucleoplasm; cytoplasmMolecular Function: metal ion bindingBiological Process: iron-sulfur cluster assembly; chromosome segregation
