The COL4A2 Antibody (CAB7657) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in immunohistochemistry and immunofluorescence applications.Col4A2 is involved in maintaining the integrity and stability of basement membranes in various tissues, including the blood vessels, kidneys, and skin. Dysregulation of Col4A2 has been implicated in a variety of diseases, such as Alport syndrome, diabetic nephropathy, and certain types of cancer. Understanding the expression and localization of Col4A2 is essential for elucidating its role in these pathologies and exploring its potential as a therapeutic target.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
COL4A2 Antibody
SKU:
CAB7657
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.
Purification Method
Affinity purification
Gene ID
1284
RRID
AB_2768993
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of lysates from HeLa cells, using COL4A2 Rabbit pAb (CAB7657) at 1:900 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 180s.
