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Anti-CDA Antibody (CAB2006)

SKU:
CAB2006
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
  • Cell Biology Antibodies 8 Anti-CDA Antibody CAB2006
  • Cell Biology Antibodies 8 Anti-CDA Antibody CAB2006
$167 - $503
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Description

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Antibody Name:Anti-CDA Antibody
Antibody SKU:CAB2006
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-146 of human CDA (NP_001776.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:HeLa, HepG2, 293T, Jurkat, SW620, Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-146 of human CDA (NP_001776.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAQK RPAC TLKP ECVQ QLLV CSQE AKKS AYCP YSHF PVGA ALLT QEGR IFKG CNIE NACY PLGI CAER TAIQ KAVS EGYK DFRA IAIA SDMQ DDFI SPCG ACRQ VMRE FGTN WPVY MTKP DGTY IVMT VQEL LPSS FGPE DLQK TQ
Gene ID:978
Uniprot:P32320
Cellular Location:
Calculated MW:16kDa
Observed MW:16kDa
Synonyms:CDA, CDD
Background:This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias.
UniProt Protein Function:CDA: This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. Belongs to the cytidine and deoxycytidylate deaminase family.
UniProt Protein Details:

Protein type:Nucleotide Metabolism - pyrimidine; Hydrolase; Xenobiotic Metabolism - drug metabolism - other enzymes; EC 3.5.4.5

Chromosomal Location of Human Ortholog: 1p36.2-p35

Cellular Component: extracellular region; cytosol

Molecular Function:protein homodimerization activity; zinc ion binding; nucleoside binding; cytidine deaminase activity

Biological Process: cell surface receptor linked signal transduction; pyrimidine base metabolic process; cytosine metabolic process; nucleobase, nucleoside and nucleotide metabolic process; pyrimidine nucleoside salvage; cytidine deamination; negative regulation of cell growth; pyrimidine salvage; negative regulation of nucleotide metabolic process; protein homotetramerization

NCBI Summary:This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. [provided by RefSeq, Jul 2008]
UniProt Code:P32320
NCBI GenInfo Identifier:1705718
NCBI Gene ID:978
NCBI Accession:P32320.2
UniProt Related Accession:P32320
Molecular Weight:
NCBI Full Name:Cytidine deaminase
NCBI Synonym Full Names:cytidine deaminase
NCBI Official Symbol:CDA  
NCBI Official Synonym Symbols:CDD  
NCBI Protein Information:cytidine deaminase
UniProt Protein Name:Cytidine deaminase
UniProt Synonym Protein Names:Cytidine aminohydrolase
Protein Family:Colicin
UniProt Gene Name:CDA  
UniProt Entry Name:CDD_HUMAN
Anti-CDA Antibody (CAB2006)Western blot analysis of extracts of various cell lines, using CDA antibody (CAB2006) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Anti-CDA Antibody (CAB2006)Immunofluorescence analysis of MCF-7 cells using CDA antibody (CAB2006). Blue: DAPI for nuclear staining.

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