The DCLRE1C Polyclonal Antibody (CAB5615) is a high-quality antibody developed for reliable detection and analysis of target proteins. This rabbit polyclonal antibody is highly specific to human samples and has been validated for use in Western blot applications. By binding to the DCLRE1C protein, this antibody allows for precise detection and analysis in various cell types, making it ideal for research in genomics, oncology, and genetic diseases.DCLRE1C, also known as ARTEMIS, is essential for repairing DNA double-strand breaks and maintaining genomic stability.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
DCLRE1C Polyclonal Antibody
SKU:
CAB5615
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
SCIDA, SNM1C, A-SCID, RS-SCID, DCLREC1C, DCLRE1C
Positive Sample:
Mouse thymus
Cellular Localization:
Nucleus.
Calculated MW:
78kDa
Observed MW:
90kDa
This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The encoded protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins. The protein also functions in the regulation of the cell cycle in response to DNA damage. Mutations in this gene can cause Athabascan-type severe combined immunodeficiency (SCIDA) and Omenn syndrome. Alternative splicing results in multiple transcript variants.
Purification Method
Affinity purification
Gene ID
64421
RRID
AB_2769122
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of lysates from Mouse thymus, using DCLRE1C Rabbit pAb (CAB5615) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 180s.
