| UniProt Protein Function: | defensin, beta 4: Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103. Belongs to the beta-defensin family.Protein type: Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 8p23.1Cellular Component: cell surface; extracellular regionBiological Process: defense response to bacterium; innate immune response |
| UniProt Protein Details: | |
| NCBI Summary: | Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 104, DEFB104A and DEFB104B, in head-to-head orientation. This gene, DEFB104A, represents the more centromeric copy. [provided by RefSeq, Oct 2014] |
| UniProt Code: | Q8WTQ1 |
| NCBI GenInfo Identifier: | 118572637 |
| NCBI Gene ID: | 140596 |
| NCBI Accession: | Q8WTQ1.2 |
| UniProt Secondary Accession: | Q8WTQ1,Q496I2, Q496I3, Q496I4 |
| UniProt Related Accession: | Q8WTQ1 |
| Molecular Weight: | Approximately 150 kDa |
| NCBI Full Name: | Beta-defensin 104 |
| NCBI Synonym Full Names: | defensin, beta 104A |
| NCBI Official Symbol: | DEFB104AÂ Â |
| NCBI Official Synonym Symbols: | BD-4; DEFB4; hBD-4; DEFB-4; DEFB104Â Â |
| NCBI Protein Information: | beta-defensin 104; defensin, beta 4 |
| UniProt Protein Name: | Beta-defensin 104 |
| UniProt Synonym Protein Names: | Beta-defensin 4; BD-4; DEFB-4; hBD-4; Defensin, beta 104 |
| Protein Family: | |
| UniProt Gene Name: | DEFB104AÂ Â |
| UniProt Entry Name: | D104A_HUMAN |
