Anti-delta Sarcoglycan Antibody (CAB9175)

SKU:
CAB9175
€129 - €349

Description

Technical Manual

Anti-delta Sarcoglycan Antibody

Product Name:Anti-delta Sarcoglycan Antibody
Product SKU:CAB9175
Size:20uL, 50 uL
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Background:

The protein encoded by this gene is one of the four known components of the sarcoglycan complex, which is a subcomplex of the dystrophin-glycoprotein complex (DGC). DGC forms a link between the F-actin cytoskeleton and the extracellular matrix. This protein is expressed most abundantly in skeletal and cardiac muscle. Mutations in this gene have been associated with autosomal recessive limb-girdle muscular dystrophy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008]

Immunogen:A synthesized peptide derived from human delta Sarcoglycan
Sequence:

Email for sequence

Gene ID:6444
Swiss Prot:Q92629
Synonyms:35DAG; CMD1L; DAGD; SG-delta; SGCDP; SGD
Calculated MW:35kDa
Observed MW:36KDa
Reactivity:Human, Mouse
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Application Key:Western blotting
Positive Samples:A-549, RD, Mouse heart
Cellular Location:

Product Images

Anti-delta Sarcoglycan Antibody (CAB9175)

Western blot - delta Sarcoglycan Rabbit mAb (CAB9175)

Uniprot Information

UniProt Protein Function:SGCD: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Defects in SGCD are the cause of limb-girdle muscular dystrophy type 2F (LGMD2F). LGMD2F is an autosomal recessive disorder. Defects in SGCD are the cause of cardiomyopathy dilated type 1L (CMD1L). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Belongs to the sarcoglycan beta/delta/gamma/zeta family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Dystrophin complex; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q33-q34

Cellular Component: dystrophin-associated glycoprotein complex; cytoskeleton; cytoplasm; integral to membrane; plasma membrane; sarcoglycan complex; sarcolemma

Biological Process: cardiac muscle development; muscle development; heart contraction; muscle cell development

Disease: Muscular Dystrophy, Limb-girdle, Type 2f; Cardiomyopathy, Dilated, 1l

NCBI Summary:The protein encoded by this gene is one of the four known components of the sarcoglycan complex, which is a subcomplex of the dystrophin-glycoprotein complex (DGC). DGC forms a link between the F-actin cytoskeleton and the extracellular matrix. This protein is expressed most abundantly in skeletal and cardiac muscle. Mutations in this gene have been associated with autosomal recessive limb-girdle muscular dystrophy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q92629
NCBI GenInfo Identifier:212276471
NCBI Gene ID:6444
NCBI Accession:Q92629.2
UniProt Secondary Accession:Q92629,Q53XA5, Q99644, A8K9S9,
UniProt Related Accession:Q92629
Molecular Weight:289
NCBI Full Name:Delta-sarcoglycan
NCBI Synonym Full Names:sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
NCBI Official Symbol:SGCD
NCBI Official Synonym Symbols:SGD; DAGD; 35DAG; CMD1L; SGCDP; SG-delta
NCBI Protein Information:delta-sarcoglycan; delta-SG; placental delta sarcoglycan; 35 kDa dystrophin-associated glycoprotein; dystrophin associated glycoprotein, delta sarcoglycan
UniProt Protein Name:Delta-sarcoglycan
UniProt Synonym Protein Names:35 kDa dystrophin-associated glycoprotein; 35DAG
Protein Family:Delta-sarcoglycan
UniProt Gene Name:SGCD
UniProt Entry Name:SGCD_HUMAN
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Additional Information

Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Cell Biology
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