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Anti-DHTKD1 Antibody (CAB8369)

SKU:
CAB8369
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Metabolism
$167 - $503
Frequently bought together:

Description

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Antibody Name:Anti-DHTKD1 Antibody
Antibody SKU:CAB8369
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human DHTKD1 (NP_061176.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:MCF7, HepG2, M21, 22Rv1, Mouse brain, Mouse liver, Mouse kidney, Rat brain, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human DHTKD1 (NP_061176.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MASA TAAA ARRG LGRA LPLL WRGY QTER GVYG YRPR KPES REPQ GALE RPPV DHGL ARLV TVYC EHGH KAAK INPL FTGQ ALLE NVPE IQAL VQTL QGPF HTAG LLNM GKEE ASLE EVLV YLNQ IYCG QISI ETSQ LQSQ DEKD WFAK RFEE LQKE TFTT EERK HLSK LMLE SQEF DHFL ATKF STVK RYGG EGAE SMMG FFHE LLKM SAYS GITD VIIG MPHR GRLN LLTG LLQF PPEL MFRK MRGL SEFP ENFS ATGD VLSH LTSS VDLY FGAH HPLH
Gene ID:55526
Uniprot:Q96HY7
Cellular Location:Mitochondrion
Calculated MW:103kDa
Observed MW:112kDa
Synonyms:DHTKD1, AMOXAD, CMT2Q
Background:This gene encodes a component of a mitochondrial 2-oxoglutarate-dehydrogenase-complex-like protein involved in the degradation pathways of several amino acids, including lysine. Mutations in this gene are associated with 2-aminoadipic 2-oxoadipic aciduria and Charcot-Marie-Tooth Disease Type 2Q.
UniProt Protein Function:DHTKD1: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3). Belongs to the alpha-ketoglutarate dehydrogenase family.
UniProt Protein Details:

Protein type:Oxidoreductase; EC 1.2.4.2

Chromosomal Location of Human Ortholog: 10p14

Cellular Component: cytosol; mitochondrial matrix; mitochondrion; oxoglutarate dehydrogenase complex

Molecular Function:oxoglutarate dehydrogenase (succinyl-transferring) activity

Biological Process: generation of precursor metabolites and energy; glyoxylate metabolic process; tricarboxylic acid cycle

Disease: 2-aminoadipic 2-oxoadipic Aciduria; Charcot-marie-tooth Disease, Axonal, Type 2q

NCBI Summary:This gene encodes a component of a mitochondrial 2-oxoglutarate-dehydrogenase-complex-like protein involved in the degradation pathways of several amino acids, including lysine. Mutations in this gene are associated with 2-aminoadipic 2-oxoadipic aciduria and Charcot-Marie-Tooth Disease Type 2Q. [provided by RefSeq, May 2013]
UniProt Code:Q96HY7
NCBI GenInfo Identifier:296434477
NCBI Gene ID:55526
NCBI Accession:Q96HY7.2
UniProt Secondary Accession:Q96HY7,Q68CU5, Q9BUM8, Q9HCE2,
UniProt Related Accession:Q96HY7
Molecular Weight:103,077 Da
NCBI Full Name:Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial
NCBI Synonym Full Names:dehydrogenase E1 and transketolase domain containing 1
NCBI Official Symbol:DHTKD1  
NCBI Official Synonym Symbols:CMT2Q; AMOXAD  
NCBI Protein Information:probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial
UniProt Protein Name:Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial
UniProt Synonym Protein Names:Dehydrogenase E1 and transketolase domain-containing protein 1
Protein Family:Probable 2-oxoglutarate dehydrogenase E1 component
UniProt Gene Name:DHTKD1  
UniProt Entry Name:DHTK1_HUMAN
Anti-DHTKD1 Polyclonal Antibody (CAB8369)Western blot analysis of extracts of various cell lines, using DHTKD1 antibody (CAB8369) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.

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