| UniProt Protein Function: | DNMT3A: a DNA methyltransferase required for genome wide de novo methylation and essential for development. DNA methylation is coordinated with methylation of histones. Prefers CpG methylation to CpA, CpT, and CpC methylation. Methylates CpG sites at a rate much slower than DNMT1, but greater than DNMT3b. Methylation is coordinated with methylation of histones. Binds the ZNF238 transcriptional repressor. Interacts with SETDB1 and DNMT1. Can co-localize with heterochromatin protein (HP1 ) and methyl-CpG binding protein (MeCBP). Associates with HDAC1 through its ADD-type zinc-finger. Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung. |
| UniProt Protein Details: | Protein type:Methyltransferase, DNA; EC 2.1.1.37; Methyltransferase; Amino Acid Metabolism - cysteine and methionine Cellular Component: nucleoplasm; XY body; heterochromatin; euchromatin; nuclear matrix; cytoplasm; nuclear heterochromatin; nucleus; chromosome, pericentric region Molecular Function:transferase activity; DNA (cytosine-5-)-methyltransferase activity; methyltransferase activity; identical protein binding; protein binding; DNA binding; DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates; unmethylated CpG binding; metal ion binding; chromatin binding Biological Process: methylation; genetic imprinting; maintenance of DNA methylation; transcription, DNA-dependent; DNA methylation during gametogenesis; S-adenosylhomocysteine metabolic process; chromatin modification; negative regulation of transcription from RNA polymerase II promoter; cytosine methylation within a CG sequence; methylation-dependent chromatin silencing; regulation of transcription, DNA-dependent; DNA methylation; S-adenosylmethioninamine metabolic process; spermatogenesis; DNA methylation during embryonic development; DNA methylation on cytosine |
| NCBI Summary: | This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Loss of function of this gene causes developmental defects in multiple different organ systems. There is a pseudogene for this gene located on chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Nov 2012] |
| UniProt Code: | O88508 |
| NCBI GenInfo Identifier: | 418203928 |
| NCBI Gene ID: | 13435 |
| NCBI Accession: | NP_001258682.1 |
| UniProt Related Accession: | O88508 |
| Molecular Weight: | 77kDa; 101kDa |
| NCBI Full Name: | DNA (cytosine-5)-methyltransferase 3A isoform 1 |
| NCBI Synonym Full Names: | DNA methyltransferase 3A |
| NCBI Official Symbol: | Dnmt3a  |
| NCBI Official Synonym Symbols: | MmuIIIAÂ Â |
| NCBI Protein Information: | DNA (cytosine-5)-methyltransferase 3A |
| UniProt Protein Name: | DNA (cytosine-5)-methyltransferase 3A |
| UniProt Synonym Protein Names: | DNA methyltransferase MmuIIIA; DNA MTase MmuIIIA; M.MmuIIIA |
| Protein Family: | DNA |
| UniProt Gene Name: | Dnmt3a  |
| UniProt Entry Name: | DNM3A_MOUSE |
