The DMAP1 Monoclonal Antibody (CAB19281) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody is raised in rabbits and specifically targets the DMAP1 protein in human samples. It has been validated for use in Western blot applications, allowing for the detection and analysis of DMAP1 in various cell types.DMAP1 is known to play a critical role in epigenetic regulation, making it a key player in processes such as transcriptional activation and chromatin remodeling. Dysregulation of DMAP1 has been linked to various diseases, including cancer and developmental disorders.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.
Product Name:
DMAP1 Monoclonal Antibody
SKU:
CAB19281
Size:
20μL, 100μL
Reactivity:
Human
Clone Number:
ARC2462
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
EAF2, SWC4, MEAF2, DNMAP1, DNMTAP1, DMAP1
Positive Sample:
HeLa, PC-12, HepG2
Cellular Localization:
Cytoplasm, Nucleus.
Calculated MW:
53kDa
Observed MW:
60kDa
This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.
Purification Method
Affinity purification
Gene ID
55929
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using DMAP1 Rabbit mAb (CAB19281) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 180s.
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