DMPO Antibody [N1664A] is a mouse monoclonal antibody directed against DMPO, offered by Assay Genie for research applications. Reported applications include WB, IHC, ICC/IF, IP, ELISA and AM. Reactivity is species independent. Supplied as IgG1, purified by Protein G.
DMPO (5,5-dimethyl-1-pyrroline N-oxide) is a widely used spin trap compound for detecting free radicals and reactive oxygen species (ROS) in biological systems. Its low toxicity and favorable pharmacokinetics make it ideal for in vivo and in vitro studies of oxidative stress—a central mechanism in neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and ALS. DMPO forms stable nitrone adducts with protein and DNA radicals, enabling precise identification of oxidative modifications that contribute to neuronal damage. These adducts serve as biomarkers for radical-induced injury, offering insights into disease progression and therapeutic response. However, the presence of nitric oxide and related reactive nitrogen species can interfere with DMPO quantification, necessitating careful experimental design. By enabling real-time detection of oxidative stress at the molecular level, DMPO supports the development of antioxidant strategies and enhances understanding of redox imbalance in neurodegeneration. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
