DNAJC10 Antibody (PACO14820)
- SKU:
- PACO14820
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | DNAJC10 Antibody (PACO14820) |
| Antibody SKU: | PACO14820 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Fusion protein of human DNAJC10 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14820(DNAJC10 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO14820(DNAJC10 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | This gene encodes an endoplasmic reticulum co-chaperone which is part of the endoplasmic reticulum-associated degradation complex involved in recognizing and degrading misfolded proteins. The encoded protein reduces incorrect disulfide bonds in misfolded glycoproteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| Synonyms: | DnaJ (Hsp40) homolog, subfamily C, member 10 |
| UniProt Protein Function: | DNAJC10: This endoplasmic reticulum co-chaperone may play a role in protein folding and translocation across the endoplasmic reticulum membrane. May act as a co-chaperone for HSPA5. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Chaperone; Endoplasmic reticulum; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 2q32.1 Cellular Component: endoplasmic reticulum; endoplasmic reticulum lumen; membrane Molecular Function:ATPase activator activity; ATPase binding; chaperone binding; disulfide oxidoreductase activity; Hsp70 protein binding; misfolded protein binding; oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor; protein binding; protein disulfide oxidoreductase activity Biological Process: ER-associated protein catabolic process; negative regulation of protein amino acid phosphorylation; positive regulation of ATPase activity |
| NCBI Summary: | This gene encodes an endoplasmic reticulum co-chaperone which is part of the endoplasmic reticulum-associated degradation complex involved in recognizing and degrading misfolded proteins. The encoded protein reduces incorrect disulfide bonds in misfolded glycoproteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012] |
| UniProt Code: | Q8IXB1 |
| NCBI GenInfo Identifier: | 142981524 |
| NCBI Gene ID: | 54431 |
| NCBI Accession: | Q8IXB1.2 |
| UniProt Secondary Accession: | Q8IXB1,Q17RJ6, Q3B7W8, Q4ZG06, Q53QT7, Q6UWZ6, Q86T61 Q8NC82, Q8TD87, Q96K38, Q96K44, Q96K54, |
| UniProt Related Accession: | Q8IXB1 |
| Molecular Weight: | 91kDa |
| NCBI Full Name: | DnaJ homolog subfamily C member 10 |
| NCBI Synonym Full Names: | DnaJ heat shock protein family (Hsp40) member C10 |
| NCBI Official Symbol: | DNAJC10 |
| NCBI Official Synonym Symbols: | JPDI; MTHr; ERdj5; PDIA19 |
| NCBI Protein Information: | dnaJ homolog subfamily C member 10 |
| UniProt Protein Name: | DnaJ homolog subfamily C member 10 |
| UniProt Synonym Protein Names: | Endoplasmic reticulum DNA J domain-containing protein 5; ER-resident protein ERdj5; ERdj5; Macrothioredoxin; MTHr |
| Protein Family: | DnaJ homolog subfamily |
| UniProt Gene Name: | DNAJC10 |
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