| UniProt Protein Function: | DNASE2B: Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation. Belongs to the DNase II family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Deoxyribonuclease; EC 3.1.22.1Chromosomal Location of Human Ortholog: 1p22.3Cellular Component: lysosome; extracellular region; intracellularMolecular Function: deoxyribonuclease II activityBiological Process: DNA fragmentation during apoptosis |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene shares considerable sequence similarity to, and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH. Unlike DNase II which is ubiquitously expressed, expression of this gene product is restricted to the salivary gland and lungs. The gene has been localized to chromosome 1p22.3 adjacent (and in opposite orientation) to the uricase pseudogene. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8WZ79 |
| NCBI GenInfo Identifier: | 194473657 |
| NCBI Gene ID: | 58511 |
| NCBI Accession: | NP_067056.2 |
| UniProt Secondary Accession: | Q8WZ79,Q5VXD0, Q5VXD1, Q8WZ80, Q9NQW3 |
| UniProt Related Accession: | Q8WZ79 |
| Molecular Weight: | 41,713 Da |
| NCBI Full Name: | deoxyribonuclease-2-beta isoform 1 |
| NCBI Synonym Full Names: | deoxyribonuclease II beta |
| NCBI Official Symbol: | DNASE2BÂ Â |
| NCBI Official Synonym Symbols: | DLADÂ Â |
| NCBI Protein Information: | deoxyribonuclease-2-beta; DNase II beta; endonuclease DLAD; lysosomal DNase II; DNase2-like acid DNase; DNase II-like acid DNase |
| UniProt Protein Name: | Deoxyribonuclease-2-beta |
| UniProt Synonym Protein Names: | DNase II-like acid DNase; DNase2-like acid DNase; Deoxyribonuclease II beta; DNase II beta; Endonuclease DLAD |
| Protein Family: | Deoxyribonuclease |
| UniProt Gene Name: | DNASE2BÂ Â |
| UniProt Entry Name: | DNS2B_HUMAN |
