The DOC2B Polyclonal Antibody (PACO08907) is an essential tool for researchers studying the DOC2B protein, a key player in calcium-dependent exocytosis. This antibody, produced using rabbit immunization, is highly specific to DOC2B and ideal for use in Western blot applications. By binding to the DOC2B protein, this antibody allows for precise detection and analysis in a variety of cell types, making it invaluable for studies in neuroscience and endocrinology.
DOC2B, a calcium-binding protein, is crucial for regulating neurotransmitter release and hormone secretion in response to elevated calcium levels. Its role in vesicle fusion and exocytosis makes it a target of interest in research on synaptic transmission and hormone regulation. Understanding the function of DOC2B can provide insights into neurological disorders and endocrine diseases, opening doors for new therapeutic approaches in these areas.
DOC2B: Calcium sensor which positively regulates SNARE- dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes.Protein type: Lipid-bindingChromosomal Location of Human Ortholog: 17p13.3Cellular Component: SNARE complex; synaptic vesicle; cytoplasm; plasma membraneMolecular Function: calcium-dependent phospholipid binding; transporter activityBiological Process: positive regulation of calcium ion-dependent exocytosis; protein localization; calcium ion-dependent exocytosis of neurotransmitter; positive regulation of insulin secretion; positive regulation of vesicle fusion
NCBI Summary:
There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2B is expressed ubiquitously and is suggested to be involved in Ca(2+)-dependent intracellular vesicle trafficking in various types of cells. [provided by RefSeq, Jul 2008]
