Description
Dog CD278/ICOS Recombinant Protein (C-dFc)
Dog CD278/ICOS Recombinant Protein (C-dFc) is a recombinant protein expressed in mammalian cells, spanning Glu21-Phe141, with a C-terminal dFc tag. Predicted molecular weight: 41.72 kDa. Purity: >95% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Inducible T-cell costimulator (CD278/ICOS) is a ~23 kDa protein. Stimulatory receptor expressed in activated or antigen-experienced T-cells that plays an important role in the immune response. For research use only.
Upon binding to its ligand ICOSL expressed on antigen presenting cells (APCs), delivers costimulatory signals that enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines including IL10, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Also acts as a costimulatory receptor critical for the differentiation of T follicular regulatory cells upon immune challenges such as viral infection. Mechanistically, potentiates TCR-induced calcium flux by augmenting PLCG1 activation and actin remodeling. In addition, activates PI3K signaling pathways independently of calcium flux.
| Product Name: | Dog CD278/ICOS Recombinant Protein (C-dFc) |
| SKU: | GXRP07054 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Canis familiaris |
| Synonyms: | Inducible T-cell costimulator, Activation-inducible lymphocyte immunomediatory molecule, CD278, ICOS, AILIM |
| Tag: | C-dFc |
| Expression Host: | Mammalian cells |
| Protein Length: | Glu21-Phe141 |
| Calculated MW: | 41.72 kDa |
| UniProt: | Q7YR73 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >95% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
