The DYNC2H1 Antibody (CAB13126) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, exhibits high specificity and sensitivity in detecting DYNC2H1 in human samples, making it an essential tool for immunohistochemistry and Western blot applications.DYNC2H1 is essential for proper cilia function and cellular movement, playing a crucial role in various developmental processes and cellular signaling pathways. Dysregulation of DYNC2H1 has been linked to ciliopathies and genetic disorders, making it a promising target for therapeutic interventions targeting cilia-related diseases.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Rat samples.
Product Name:
DYNC2H1 Antibody
SKU:
CAB13126
Size:
20μL, 100μL
Reactivity:
Rat
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
This gene encodes a large cytoplasmic dynein protein that is involved in retrograde transport in the cilium and has a role in intraflagellar transport, a process required for ciliary/flagellar assembly. Mutations in this gene cause a heterogeneous spectrum of conditions related to altered primary cilium function and often involve polydactyly, abnormal skeletogenesis, and polycystic kidneys. Alternative splicing results in multiple transcript variants encoding distinct proteins.
Purification Method
Affinity purification
Gene ID
79659
RRID
AB_2759975
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from rat testis, using DYNC2H1 Rabbit pAb (CAB13126) at 1:3000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (AbGn00021). Exposure time: 30s.
