Efmirenpase alfa (Research-Grade) is a research-grade biosimilar antibody targeting ENPP1. Format: ENPP1-Fc. Reactivity: Human. Supplied as a liquid in 0.01M PBS pH 7.4. Applications: functional assays. Endotoxin: < 10 EU/mg. Purity: >95% as determined by SDS-PAGE. For research use only.
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 is a ~104 kDa protein. Nucleotide pyrophosphatase that generates diphosphate (PPi) and functions in bone mineralization and soft tissue calcification by regulating pyrophosphate levels. PPi inhibits bone mineralization and soft tissue calcification by binding to nascent hydroxyapatite crystals, thereby preventing further growth of these crystals. Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP and UTP to their corresponding monophosphates with release of pyrophosphate, as well as diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Inhibits ectopic joint calcification and maintains articular chondrocytes by repressing hedgehog signaling; it is however unclear whether hedgehog inhibition is direct or indirect.
Product Name:
Efmirenpase alfa (Research-Grade)
SKU:
GXBS02647
Size:
100 µg, 1 mg
Target:
ENPP1
Isotype:
ENPP1-Fc
Reactivity:
Human
Applications:
Functional assay
Synonyms:
CAS: 2770242-54-9
Purity:
>95% as determined by SDS-PAGE
Endotoxin Level:
< 10 EU/mg
Formulation:
0.01M PBS pH 7.4
Regulatory Status:
For research use only.
Storage and Handling:
Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
