ENaC beta Antibody [7B8] is a mouse monoclonal antibody directed against ENaC beta, offered by Assay Genie for research applications. Reported applications include WB and IHC. Reported reactivity: Mouse. Supplied as IgG1, purified by Protein G.
The beta subunit of the epithelial sodium channel (ENaCβ) is essential for the functional assembly and regulation of the ENaC complex, which governs sodium absorption across epithelial surfaces. While ENaCβ is well-characterized in renal and pulmonary physiology, its emerging role in the nervous system is drawing increasing interest in neurodegenerative disease research. ENaCβ is critical for fluid clearance in distal lung epithelia, particularly in response to edema, and its expression is upregulated during keratinocyte differentiation—highlighting its involvement in cellular stress adaptation. In the retina, ENaCβ is differentially expressed under conditions of ocular hypertension, suggesting a role in neurovascular regulation and intraocular pressure homeostasis. These mechanisms are relevant to neurodegenerative diseases where fluid imbalance, oxidative stress, and ion dysregulation contribute to neuronal injury. Recent studies propose that ENaCβ may influence glial cell function, neuroinflammation, and blood-brain barrier integrity—key factors in the progression of disorders such as Parkinson’s disease and ALS. As a regulator of sodium flux and tissue hydration, ENaCβ represents a promising target for modulating neuroimmune responses and preserving neural function. By bridging epithelial ion transport and neural health, ENaCβ offers a novel perspective in the search for biomarkers and therapeutic strategies in neurodegeneration. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
Product Name:
ENaC beta Antibody [7B8]
Product SKU:
STMA00070
Size:
100 µg
Target:
ENaC beta
Host Species:
Mouse
Antibody Type:
Monoclonal
Clone ID:
7B8
Research Areas:
Neuroscience, Ion Channels, Sodium Channels, Epithelial Sodium Channels (ENaC)
Buffer:
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage & Shipping:
Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:
Liquid
Applications:
WB, IHC
Antibody Isotype:
IgG1
Purification:
Protein G Purified
Concentration:
1 mg/ml
Reactivity:
Mouse
Recommended Dilution:
WB (1:1000); IHC (1:150); optimal dilutions for assays should be determined by the user.
Specificity:
Detects ~87kDa.
Guarantee:
12 months from date of dispatch
Immunogen:
Synthetic peptide from the C-terminal of Rat ENaC beta (aa. 617-638)
