ENaC gamma Antibody is a rabbit polyclonal antibody directed against ENaC gamma, offered by Assay Genie for research applications. Reported applications include WB, IHC and ICC/IF. Reported reactivity: Rat, Mouse, African clawed frog (Xenopus laevis), Hamster and Human. Purified by Protein A.
The gamma subunit of the epithelial sodium channel (ENaCγ) is a vital component of the heterotrimeric ENaC complex, which regulates sodium ion transport across epithelial surfaces. While ENaCγ is traditionally associated with fluid and electrolyte balance in organs such as the kidney, lung, and colon, its emerging role in the nervous system is gaining attention in neurodegenerative disease research. ENaCγ, in conjunction with the beta subunit, is essential for efficient fluid absorption in distal lung epithelia, particularly under edematous conditions. This functional synergy suggests a broader role in maintaining tissue homeostasis under stress. In the retina, differential expression of ENaC subunits—including ENaCγ—has been observed in models of ocular hypertension, implicating ENaCγ in neuroprotective responses to elevated intraocular pressure, a key risk factor in glaucoma. Recent insights propose that ENaCγ may influence neural cell volume regulation, glial activation, and blood-brain barrier integrity—processes that are disrupted in neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and multiple sclerosis. Its mechanosensitive properties and role in sodium flux position ENaCγ as a potential modulator of neuroinflammation and ionic imbalance in the central nervous system. As the field of neuroionics expands, ENaCγ is emerging as a promising target for therapeutic development and biomarker discovery in neurodegeneration, bridging epithelial physiology and neural resilience. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
Product Name:
ENaC gamma Antibody
Product SKU:
STPA00049
Size:
100 µg
Target:
ENaC gamma
Host Species:
Rabbit
Antibody Type:
Polyclonal
Research Areas:
Neuroscience, Neurotransmission, Ion Channels, Sodium Channels, Epithelial Sodium Channels (ENaC)
Buffer:
PBS, 50% glycerol, 0.09% sodium azide
Storage & Shipping:
Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:
Liquid
Applications:
WB, IHC, ICC/IF
Purification:
Protein A Purified
Concentration:
1 mg/ml
Reactivity:
Rat, Mouse, African clawed frog (Xenopus laevis), Hamster, Human
Recommended Dilution:
WB (1:1000), IHC (1:100); optimal dilutions for assays should be determined by the user.
Specificity:
Detects ~83kDa.
Guarantee:
12 months from date of dispatch
Immunogen:
Produced against the C-terminal tail (amino acids 629-650) of rat gamma ENaC (antibody designation L550)
