EndoPDI Antibody [2E7/7] is a mouse monoclonal antibody directed against EndoPDI, offered by Assay Genie for research applications. Reported applications include WB, IHC, ICC/IF, IP and ELISA. Reported reactivity: Human. Supplied as IgG2a, purified by Protein G.
Protein disulfide isomerase (PDI) is a thiol-disulfide oxidoreductase that facilitates protein folding and quality control in the endoplasmic reticulum (ER). In neurons, PDI plays a protective role by preventing the accumulation of misfolded proteins and maintaining redox homeostasis. Under conditions of ER stress—common in neurodegenerative diseases—PDI expression is upregulated as part of the unfolded protein response (UPR). However, excessive or dysfunctional PDI activity has been linked to protein aggregation and oxidative damage in Alzheimer’s, ALS, and Parkinson’s disease. PDI’s dual role in neuroprotection and pathology makes it a compelling target for therapeutic strategies aimed at modulating ER stress and proteostasis in neurodegeneration. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
Product Name:
EndoPDI Antibody [2E7/7]
Product SKU:
STMA00059
Size:
100 µg
Target:
EndoPDI
Host Species:
Mouse
Antibody Type:
Monoclonal
Clone ID:
2E7/7
Research Areas:
Cell Signaling, Protein Trafficking, Chaperone Proteins, Organelle Markers
Buffer:
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage & Shipping:
Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:
Liquid
Applications:
WB, IHC, ICC/IF, IP, ELISA
Antibody Isotype:
IgG2a
Purification:
Protein G Purified
Concentration:
1 mg/ml
Reactivity:
Human
Recommended Dilution:
WB (1:200); optimal dilutions for assays should be determined by the user.
Specificity:
Detects ~48kDa.
Guarantee:
12 months from date of dispatch
Immunogen:
Synthesized peptide - 12 amino acids long (ADGEDGQDPHSK) corresponding to residues 52 - 63 of the Human EndoPDI protein
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