Enfortumab ELISA Kit (GXEL00240)

Enfortumab ELISA Kit

Assay Genie's Enfortumab ELISA Kit (SKU: GXEL00240) provides researchers with a reliable quantitative ELISA for the quantitative measurement of Enfortumab in Plasma, Serum. Offering a measurement range of 93.75 - 1, 500 ng/mL and a sensitivity of 47.39 ng/mL, the kit is optimised for precision and ease of use in the research laboratory.

Enfortumab vedotin is an antibody-drug conjugate (ADC) designed for the treatment of cancer expressing Nectin-4. It was developed through two main lines, hybridoma (ASG-22ME) and Chinese hamster ovary (ASG-22CE). Enfortumab refers to the fully humanized (from mouse) monoclonal antibody (mAb) created by scientists at Agensys (part of Astellas) using Amgen’s transgenic system (XenoMouse), it is the first agent to target Nectin-4 that expressed on many solid tumors especially on bladder cancers. Vedotin refers to the payload drug microtubule-disrupting agent monomethyl auristatin E (MMAE) and the linker. The linker technology holding the antibody and the toxin together was provided by and licensed from Seattle Genetics. Preclinical studies showed that enfortumab vedotin effectively binds to target cells, internalizes and induces cell-killing activity. Mouse and patient xenograft models were used to test enfortumab vedotin’s antitumor activity in human breast, bladder, pancreatic and lung cancers. In March 2018, Seattle Genetics and Astellas received the U.S. Food and Drug Administration (FDA) Breakthrough Therapy Designation for enfortumab vedotin based on interim results from the phase 1 study examining enfortumab vedotin as monotherapy treatment for patients with metastatic urothelial cancer who were previously treated with checkpoint inhibitors.

Complete with standards, buffers and detection reagents, the Enfortumab ELISA Kit streamlines assay set-up so you can focus on results. Choose the Enfortumab ELISA Kit from Assay Genie for quality you can trust.