Ensovibep (Research-Grade) is a research-grade biosimilar monoclonal antibody. Format: DARpin. Reactivity: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Supplied as a lyophilized in Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, functional assays and in vivo research. Endotoxin: < 10 EU/mg. Purity: >90% purity as determined by SDS-PAGE. For research use only.
Spike glycoprotein (RBD) is a ~141 kDa protein. Attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. The major receptor is host ACE2. When S2/S2' has been cleaved, binding to the receptor triggers direct fusion at the cell membrane. When S2/S2' has not been cleaved, binding to the receptor results in internalization of the virus by endocytosis using host TFRC and GRM2 and leading to fusion of the virion membrane with the host endosomal membrane. Alternatively, may use NRP1/NRP2 and integrin as entry receptors.
Product Name:
Ensovibep (Research-Grade)
SKU:
GXBS00867
Size:
100 µg, 1 mg
Antibody Type:
Monoclonal Antibody
Target:
Spike glycoprotein
Isotype:
DARpin
Reactivity:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Fusion-[human activin receptor type 2-A (activin receptor type IIA, ACTR-IIA) extracellular domain (ECD) fragment (1-109) engineered varian]2-IgG1-Fc (Fragment constant)
