Erlizumab Antibody is a research-grade biosimilar monoclonal antibody targeting Complement receptor C3 subunit beta. It is a humanized IgG1-nd antibody. Reactivity: Human. Supplied as a liquid in 0.01M PBS pH 7.4. Applications: ELISA, flow cytometry, functional assays and in vivo research. Endotoxin: < 10 EU/mg. Purity: >95% as determined by SDS-PAGE. For research use only.
Integrin beta-2 (Complement receptor C3 subunit beta,Cell surface adhesion glycoproteins LFA-1/CR3) is a ~84 kDa protein. Integrin ITGAL:ITGB2 is a receptor for ICAM1, ICAM2 and ICAM3. Integrin ITGAL:ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM:ITGB2 and ITGAX:ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX:ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM:ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. 1. de Fougerolles, AR. et al. (1991) The Journal of experimental medicine 174, 253-67. PMID: 1676048 2. Kristóf, E. et al. (2013) Apoptosis : an international journal on programmed cell death 18, 1235-51. PMID: 23775590 3. Lacouture, C. et al. (2024) Nature communications 15, 407. PMID: 38195629 4. Swaim, CD. et al. (2017) Molecular cell 68, 581-590.e5. PMID: 29100055 5. Van der Vieren, M. et al. (1999) Journal of immunology (Baltimore, Md. : 1950) 163, 1984-90. PMID: 10438935 6. Van der Vieren, M. et al. (1995) Immunity 3, 683-90. PMID: 8777714 7. Grayson, MH. et al. (1998) The Journal of experimental medicine 188, 2187-91. PMID: 9841932 8. Barber, DF. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 173, 3653-9. PMID: 15356110 9. Ostermann, G. et al. (2002) Nature immunology 3, 151-8. PMID: 11812992 10. Bai, M. et al. (2017) Blood 130, 2092-2100. PMID: 28807980
Product Name:
Erlizumab Antibody
SKU:
GXBS00085
Size:
100 µg, 1 mg
Antibody Type:
Monoclonal Antibody
Target:
CD18
Isotype:
IgG1-nd
Host Species:
Human
Reactivity:
Human
Applications:
ELISA, FCM, Functional assay, Research in vivo
Synonyms:
rhuMAb, 211323-03-4
Purity:
>95% as determined by SDS-PAGE.
Endotoxin Level:
< 10 EU/mg
Formulation:
0.01M PBS pH 7.4.
State of Matter:
Liquid
Regulatory Status:
For research use only. Not suitable for clinical or therapeutic use.
Product Preparation:
Protein A/G purified from cell culture supernatant.
Storage and Handling:
Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
