Etakafusp Alfa (Research-Grade) is a research-grade biosimilar monoclonal antibody targeting CD8. Reactivity: Human. Supplied as a liquid in 0.01M PBS pH 7.4. Applications: ELISA, functional assays and in vivo research. Endotoxin: < 10 EU/mg. Purity: >95% purity as determined by SDS-PAGE. For research use only.
T-cell surface glycoprotein CD8 alpha chain (CD8 & IL2) is a ~25 kDa protein. Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex.
Product Name:
Etakafusp Alfa (Research-Grade)
SKU:
GXBS02354
Size:
100 µg, 1 mg
Antibody Type:
Monoclonal Antibody
Target:
CD8a
Isotype:
Humanized immunoglobulin G1-kappa anti-(human CD8) fused at the C-terminus of one heavy chain, via peptide linker to a variant of human IL2
Host Species:
Human
Reactivity:
Human
Applications:
ELISA, Functional assay, Research in vivo
Synonyms:
2852680-28-3
Purity:
>95% as determined by SDS-PAGE.
Endotoxin Level:
< 10 EU/mg
Formulation:
0.01M PBS pH 7.4.
State of Matter:
Liquid
Regulatory Status:
For research use only. Not suitable for clinical or therapeutic use.
Product Preparation:
Protein A/G purified from cell culture supernatant.
Storage and Handling:
Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Human alkaline phosphatase, tissue-nonspecific isozyme/AP-TNAP soluble fragment fused to a human immunoglobulin G4 heavy chain constant region fragment fused to a deca-aspartate peptide, disulfide bridged dimer.
