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Anti-FCGR3B Antibody (CAB7894)

SKU:
CAB7894
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

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Antibody Name:Anti-FCGR3B Antibody
Antibody SKU:CAB7894
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-233 of human FCGR3B (NP_000561.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Jurkat, Raji, U-937, THP-1, Mouse liver, Mouse spleen, Mouse thymus, Rat spleen
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-233 of human FCGR3B (NP_000561.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MWQL LLPT ALLL LVSA GMRT EDLP KAVV FLEP QWYS VLEK DSVT LKCQ GAYS PEDN STQW FHNE NLIS SQAS SYFI DAAT VNDS GEYR CQTN LSTL SDPV QLEV HIGW LLLQ APRW VFKE EDPI HLRC HSWK NTAL HKVT YLQN GKDR KYFH HNSD FHIP KATL KDSG SYFC RGLV GSKN VSSE TVNI TITQ GLAV STIS SFSP PGYQ VSFC LVMV LLFA VDTG LYFS VKTN I
Gene ID:2215
Uniprot:O75015
Cellular Location:Cell membrane, GPI-anchor, Lipid-anchor, Secreted
Calculated MW:26kDa
Observed MW:26kDa/46kDa
Synonyms:FCGR3B, CD16, CD16b, FCG3, FCGR3, FCR-10, FCRIII, FCRIIIb
Background:The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1.
UniProt Protein Function:Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.
NCBI Summary:The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1. [provided by RefSeq, Aug 2012]
UniProt Code:O75015
NCBI GenInfo Identifier:7994572
NCBI Gene ID:2215
NCBI Accession:O75015.2
UniProt Related Accession:O75015
Molecular Weight:
NCBI Full Name:Low affinity immunoglobulin gamma Fc region receptor III-B
NCBI Synonym Full Names:Fc fragment of IgG receptor IIIb
NCBI Official Symbol:FCGR3B  
NCBI Official Synonym Symbols:CD16; FCG3; CD16A; CD16b; FCGR3; FCGR3A; FCR-10; FCRIII; FCRIIIb  
NCBI Protein Information:low affinity immunoglobulin gamma Fc region receptor III-B
UniProt Protein Name:Low affinity immunoglobulin gamma Fc region receptor III-B
UniProt Synonym Protein Names:Fc-gamma RIII-beta; Fc-gamma RIII; Fc-gamma RIIIb; FcRIII; FcRIIIb; FcR-10; IgG Fc receptor III-1; CD_antigen: CD16b
UniProt Gene Name:FCGR3B  
Anti-FCGR3B Antibody (CAB7894)Western blot analysis of extracts of various cell lines, using FCGR3B antibody (CAB7894) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 60s.

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