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Anti-FGF1 Antibody (CAB0685)

SKU:
CAB0685
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cardiovascular
  • Cardiovascular Antibodies Anti-FGF1 Antibody CAB0685
  • Cardiovascular Antibodies Anti-FGF1 Antibody CAB0685
  • Cardiovascular Antibodies Anti-FGF1 Antibody CAB0685
€139 - €419
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Description

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Antibody Name:Anti-FGF1 Antibody
Antibody SKU:CAB0685
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 16-155 of human FGF1 (NP_001138364.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:100 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:293T
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 16-155 of human FGF1 (NP_001138364.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:FNLP PGNY KKPK LLYC SNGG HFLR ILPD GTVD GTRD RSDQ HIQL QLSA ESVG EVYI KSTE TGQY LAMD TDGL LYGS QTPN EECL FLER LEEN HYNT YISK KHAE KNWF VGLK KNGS CKRG PRTH YGQK AILF LPLP VSSD
Gene ID:2246
Uniprot:P05230
Cellular Location:Cytoplasm, Nucleus, Secreted, cell cortex, cytosol
Calculated MW:6kDa/17kDa
Observed MW:17kDa
Synonyms:FGF1, AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1
Background:The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described.
UniProt Protein Function:FGF1: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu(2+)-dependent multiprotein aggregate containing FGF1, S100A13 and SYT1. Interacts with SYT1. Interacts with S100A13. Belongs to the heparin-binding growth factors family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Cell development/differentiation; Cytokine

Chromosomal Location of Human Ortholog: 5q31

Cellular Component: nucleoplasm; extracellular space; proteinaceous extracellular matrix; nucleolus; extracellular region; cell cortex; cytosol

Molecular Function:heparin binding; protein binding; growth factor activity; Hsp70 protein binding; fibroblast growth factor receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; anatomical structure morphogenesis; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; multicellular organismal development; positive regulation of cholesterol biosynthetic process; signal transduction; positive regulation of MAP kinase activity; positive regulation of angiogenesis; induction of an organ; positive regulation of cell division; positive regulation of cell proliferation; insulin receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; positive regulation of epithelial cell proliferation; positive regulation of cell migration; lung development

NCBI Summary:The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]
UniProt Code:P05230
NCBI GenInfo Identifier:122737
NCBI Gene ID:2246
NCBI Accession:P05230.1
UniProt Secondary Accession:P05230,P07502, Q16588, B2R5T0, D3DQF2,
UniProt Related Accession:P05230
Molecular Weight:6,698 Da
NCBI Full Name:Fibroblast growth factor 1
NCBI Synonym Full Names:fibroblast growth factor 1 (acidic)
NCBI Official Symbol:FGF1  
NCBI Official Synonym Symbols:AFGF; ECGF; FGFA; ECGFA; ECGFB; FGF-1; HBGF1; HBGF-1; GLIO703; ECGF-beta; FGF-alpha  
NCBI Protein Information:fibroblast growth factor 1; heparin-binding growth factor 1; beta-endothelial cell growth factor; endothelial cell growth factor, beta; endothelial cell growth factor, alpha
UniProt Protein Name:Fibroblast growth factor 1
UniProt Synonym Protein Names:Acidic fibroblast growth factor; aFGF; Endothelial cell growth factor; ECGF; Heparin-binding growth factor 1; HBGF-1
Protein Family:Fibroblast growth factor
UniProt Gene Name:FGF1  
UniProt Entry Name:FGF1_HUMAN
Anti-FGF1 Antibody (CAB0685)Western blot analysis of extracts of 293T cells, using FGF1 antibody (CAB0685) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 20s.
Anti-FGF1 Antibody (CAB0685)Immunohistochemistry of paraffin-embedded mouse brain using FGF1 antibody (CAB0685) at dilution of 1:100 (40x lens).
Anti-FGF1 Antibody (CAB0685)Immunohistochemistry of paraffin-embedded rat brain using FGF1 antibody (CAB0685) at dilution of 1:100 (40x lens).

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