ApplicationsELISA, FCM, Functional assay, Research in vivo
IsotypeChimeric IgG1-kappa anti-human EGFR fused at the C-terminus of both light chains, via a peptide linker, to a fragment of the extracellular domain of human TGFR-2
SKU:
GXBS02355
UPC:
Product Type:
Research Grade Biosimilar
Antibody Type:
Monoclonal
Host Species:
Chimeric
Reactivity:
Human
Applications:
ELISA, FCM, Functional assay, Research in vivo
Isotype:
Chimeric IgG1-kappa anti-human EGFR fused at the C-terminus of both light chains, via a peptide linker, to a fragment of the extracellular domain of human TGFR-2
Ficerafusp Alfa (Research-Grade) is a research-grade biosimilar monoclonal antibody targeting HER1. Reactivity: Human. Supplied as a liquid in 0.01M PBS pH 7.4. Applications: ELISA, flow cytometry, functional assays and in vivo research. Endotoxin: < 10 EU/mg. Purity: >95% purity as determined by SDS-PAGE. For research use only.
Epidermal growth factor receptor (EGFR/ERBB1 & TGFBR2) is a ~134 kDa protein. Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules.
Product Name:
Ficerafusp Alfa (Research-Grade)
SKU:
GXBS02355
Size:
100 µg, 1 mg
Antibody Type:
Monoclonal Antibody
Target:
EC:2.7.10.1
Isotype:
Chimeric IgG1-kappa anti-human EGFR fused at the C-terminus of both light chains, via a peptide linker, to a fragment of the extracellular domain of human TGFR-2
Host Species:
Chimeric
Reactivity:
Human
Applications:
ELISA, FCM, Functional assay, Research in vivo
Synonyms:
2764727-44-6
Purity:
>95% as determined by SDS-PAGE.
Endotoxin Level:
< 10 EU/mg
Formulation:
0.01M PBS pH 7.4.
State of Matter:
Liquid
Regulatory Status:
For research use only. Not suitable for clinical or therapeutic use.
Product Preparation:
Protein A/G purified from cell culture supernatant.
Storage and Handling:
Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Human alkaline phosphatase, tissue-nonspecific isozyme/AP-TNAP soluble fragment fused to a human immunoglobulin G4 heavy chain constant region fragment fused to a deca-aspartate peptide, disulfide bridged dimer.
