Firsekibart Antibody is a research-grade biosimilar monoclonal antibody targeting IL1B/IL1F2. It is a human IgG4, lambda2 antibody. Reactivity: Human. Supplied as a liquid. Applications: ELISA, flow cytometry, functional assays and in vivo research. Endotoxin: < 10 EU/mg. Purity: >95% as determined by SDS-PAGE. For research use only.
Interleukin-1 beta (IL1B/IL1F2) is a ~30 kDa protein. Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. IL1B is the therapeutic target of canakinumab (Ilaris).
Product Name:
Firsekibart Antibody
SKU:
GXBS02496
Size:
100 µg, 1 mg
Antibody Type:
Monoclonal Antibody
Target:
IL1B/IL1F2
Isotype:
IgG4, lambda2
Host Species:
Human
Reactivity:
Human
Applications:
ELISA, FACS, Functional assay, Research in vivo
Synonyms:
2981430-39-9
Purity:
>95% as determined by SDS-PAGE.
Endotoxin Level:
< 10 EU/mg
State of Matter:
Liquid
Regulatory Status:
For research use only. Not suitable for clinical or therapeutic use.
Storage and Handling:
Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
