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FITC Anti-Human CD40 Antibody [3A8] (AGEL2794)

Datasheet MSDS
SKU AGEL2794
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FCM
Reactivity Human
Host Species Mouse
Isotype Mouse IgG2a, κ
Clone 3A8
Conjugation FITC
€69 - €330

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Description

system_update_altDatasheetsystem_update_altMSDS

FITC Anti-Human CD40 Antibody [3A8]

The FITC Anti-Human CD40 Antibody (3A8) is a cutting-edge tool designed for researchers studying the CD40 cell surface molecule, a vital player in immune signaling pathways. This antibody, specifically engineered for use with human samples, has been meticulously validated for various applications, with a strong reactivity profile. By targeting the CD40 protein, researchers can efficiently detect and analyze its expression in different cell types, making it an invaluable asset in immunology and cancer research.CD40 is a key immune regulator, known for its role in activating immune responses and influencing critical cellular functions.

By studying CD40, researchers can gain insights into immune system modulation, inflammation regulation, and potential therapeutic interventions. This antibody offers a precise tool for investigating the functions of CD40 in diseases such as cancer, autoimmune disorders, and inflammatory conditions. Its reliability and specificity make it an indispensable resource for unraveling the complexities of immune response modulation and developing targeted treatments for various medical conditions.

Product Title:FITC Anti-Human CD40 Antibody [3A8]
SKU:AGEL2794
Size:20 Tests, 100 Tests, 200 Tests
Clone No:3A8
Synonyms:Tumor necrosis factor receptor superfamily member 5;Cd40;B-cell surface antigen CD40;Bp50;CD40L receptor;CD40;Tnfrsf5;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:FITC Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:FITC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P25942
Gene ID:958
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD40 is a 48 kD type I glycoprotein also known as BP50. It is a member of the TNFR superfamily primarily expressed on B cells, macrophages, follicular dendritic cells, endothelial cells, fibroblasts, and at low levels on plasma cells. CD40 has been reported to be involved in B cell differentiation, costimulation, isotype class-switching, and protection of B cells from apoptosis. Additionally, CD40 is important for T cell-B cell interactions. The ligand of CD40 is CD154 (CD40 ligand). The 5C3 antibody has been reported to promote B cell proliferation in the presence of anti-IgM, IL-4 or PMA, partially blocking CD40 binding to CD40L, and B cells rescue from apoptosis.
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