FKBP51 Antibody [Hi51B] is a mouse monoclonal antibody directed against FKBP51, offered by Assay Genie for research applications. Reported applications include WB and ICC/IF. Reported reactivity: Human, Mouse, Rat, Rabbit, Dog and Hamster. Supplied as IgG1, purified by Protein G.
FKBP51 (FK506-binding protein 5) is a co-chaperone of the Hsp90 complex and a key regulator of glucocorticoid receptor sensitivity, stress response, and protein folding. In the brain, FKBP51 modulates neuronal plasticity, inflammation, and tau protein stability—factors central to neurodegenerative disease progression. Elevated FKBP51 expression has been observed in Alzheimer’s disease and is associated with increased tau aggregation and impaired autophagy. Its role in stress hormone signaling also links FKBP51 to mood disorders and cognitive decline, making it a molecular bridge between chronic stress and neurodegeneration. Targeting FKBP51 offers a novel approach to modulate stress-related neurotoxicity and restore proteostasis in aging and diseased brains. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
Product Name:
FKBP51 Antibody [Hi51B]
Product SKU:
STMA00021
Size:
100 µg
Target:
FKBP51
Host Species:
Mouse
Antibody Type:
Monoclonal
Clone ID:
Hi51B
Research Areas:
Cancer, Heat Shock, Cell Signaling, Protein Trafficking, Nuclear Import/Export
Buffer:
PBS, 50% glycerol, 0.09% sodium azide
Storage & Shipping:
Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:
Liquid
Applications:
WB, ICC/IF
Antibody Isotype:
IgG1
Purification:
Protein G Purified
Concentration:
1 mg/ml
Reactivity:
Human, Mouse, Rat, Rabbit, Dog, Hamster
Recommended Dilution:
WB (1:2000), ICC/IF (1:1000); optimal dilutions for assays should be determined by the user.
Specificity:
Detects ~51kDa.
Guarantee:
12 months from date of dispatch
Immunogen:
Recombinant human FKBP51 fragment
Immunogen Species:
Human
Accession Number:
NP_001139247.1
Gene ID:
2289
Swiss-Prot:
Q13451
Cellular Localization:
Cytoplasm | Nucleus
Alternative Names:
AIG6, FK506 binding protein 5, FKBP5, FKBP54, HSP90 binding immunophilin, p54, Pplase, Ptg10, Rotamase, T cell FK506 binding protein
References:
1. Cheung-Flynn J., Roberts P.J., Riggs D.L., and Smith D.F.(2003) J. Biol. Chem. 278(19): 17388-17394. 2. Davies T.H., Ning Y.N., and Sanchez E.R. (2002) J Biol. Chem. 277 (7): 4597-4600. 3. Wu B. et al. (2004) Proc. Natl. Acad. Sci. USA. 101(22): 8348-8353. 4. Denny W.B., Prapapanich V., Smith D.F., and Scammell J.G. (2005) Endocrinology 146(7): 3194-3201. 5. Hubler T.R. et al. (2003) Endocrinology 144(6): 2380- 2387.
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