FKBP52 Antibody [Hi52C] is a mouse monoclonal antibody directed against FKBP52, offered by Assay Genie for research applications. Reported applications include WB, IHC, ICC/IF and IP. Reported reactivity: Human, Mouse, Rat, Dog and Hamster. Supplied as IgG2a, purified by Protein G.
FKBP52 (FK506-binding protein 4) is a co-chaperone that interacts with Hsp90 and steroid hormone receptors, influencing protein trafficking, microtubule dynamics, and neuronal signaling. In the nervous system, FKBP52 plays a protective role by regulating tau protein conformation and preventing its pathological aggregation. Reduced FKBP52 levels have been linked to increased tau pathology in Alzheimer’s disease, suggesting a neuroprotective function. FKBP52 also modulates axonal transport and synaptic stability, processes that are disrupted in several neurodegenerative conditions. As a regulator of both protein homeostasis and cytoskeletal integrity, FKBP52 represents a promising therapeutic target for halting or reversing neurodegenerative processes. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
Product Name:
FKBP52 Antibody [Hi52C]
Product SKU:
STMA00022
Size:
100 µg
Target:
FKBP52
Host Species:
Mouse
Antibody Type:
Monoclonal
Clone ID:
Hi52C
Research Areas:
Cancer, Heat Shock, Cell Signaling, Protein Trafficking, Nuclear Import/Export
Buffer:
PBS, 50% glycerol, 0.09% sodium azide
Storage & Shipping:
Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:
Liquid
Applications:
WB, IHC, ICC/IF, IP
Antibody Isotype:
IgG2a
Purification:
Protein G Purified
Concentration:
1 mg/ml
Reactivity:
Human, Mouse, Rat, Dog, Hamster
Recommended Dilution:
WB (1:2000), IHC (1:250), ICC/IF (1:1000), IP (5µg); optimal dilutions for assays should be determined by the user.
Specificity:
Detects ~52kDa. Heavy chain migrates close to FKBP52 on SDS PAGE.
Guarantee:
12 months from date of dispatch
Immunogen:
Recombinant full-length human FKBP52 protein
Immunogen Species:
Human
Accession Number:
NP_002005.1
Gene ID:
2288
Swiss-Prot:
Q02790
Cellular Localization:
Cytoplasm | Nucleus
Alternative Names:
FK506 binding protein 4, FKBP4, FKBP59, HBI, HSP56, p52, p59, PPIase, Rotamase, T cell FK506 binding protein
References:
1. Cheung-Flynn J., Roberts P.J., Riggs D.L., and Smith D.F. (2003) J. Biol. Chem. 278(19): 17388-17394. 2. Davies T.H., Ning Y.N., and Sanchez E.R. (2002) J Biol. Chem. 277 (7): 4597-4600. 3. Wu, B. et al. (2004) Proc. Natl. Acad. Sci. USA. 101(22): 8348-8353. 4. Denny W.B., Prapapanich V., Smith D.F., and Scammell J.G. (2005) Endocrinology 146(7):3194-3201. 5. Cox M.B. et al. (2007) Molecular Endocrinology. Epub.
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