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Anti-FOXP1 Antibody (CAB5272)

SKU:
CAB5272
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling
  • Epigenetics and Nuclear Signaling Antibodies 3 Anti-FOXP1 Antibody CAB5272
  • Epigenetics and Nuclear Signaling Antibodies 3 Anti-FOXP1 Antibody CAB5272
€139 - €419
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Description

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Antibody Name:Anti-FOXP1 Antibody
Antibody SKU:CAB5272
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-114 of human FOXP1 (NP_001012523.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human
Positive Samples:K-562, A-549, Raji
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-114 of human FOXP1 (NP_001012523.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MMQE SGTE TKSN GSAI QNGS GGSN HLLE CGGL REGR SNGE TPAV DIGA ADLA HAQQ QQQQ WHLI NHQP SRSP SSWL KRLI SSPW ELEV LQVP LWGA VAET KMSG PVCQ PNPS PF
Gene ID:27086
Uniprot:Q9H334
Cellular Location:Nucleus
Calculated MW:12kDa/54kDa/65kDa/66kDa/74kDa/75kDa/77kDa
Observed MW:110kDa
Synonyms:FOXP1, 12CC4, HSPC215, MFH, QRF1, hFKH1B
Background:This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms.
UniProt Protein Function:FOXP1: Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development. Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 3p13

Cellular Component: nucleoplasm; nucleus

Molecular Function:androgen receptor binding; protein binding; protein self-association

Biological Process: endothelial cell activation; macrophage activation; monocyte activation; negative regulation of B cell apoptosis; negative regulation of transcription, DNA-dependent; osteoclast differentiation; positive regulation of smooth muscle cell proliferation; regulation of inflammatory response; regulation of interleukin-1 beta secretion; regulation of monocyte differentiation; regulation of tumor necrosis factor production; response to lipopolysaccharide; somatic stem cell maintenance

Disease: Mental Retardation With Language Impairment And With Or Without Autistic Features

NCBI Summary:This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Code:Q9H334
NCBI GenInfo Identifier:14548062
NCBI Gene ID:27086
NCBI Accession:Q9H334.1
UniProt Secondary Accession:Q9H334,Q8NAN6, Q9BSG9, Q9H332, Q9H333, Q9P0R1, A3QVP8 B3KV70, G5E9V8,
UniProt Related Accession:Q9H334
Molecular Weight:75kDa
NCBI Full Name:Forkhead box protein P1
NCBI Synonym Full Names:forkhead box P1
NCBI Official Symbol:FOXP1  
NCBI Official Synonym Symbols:MFH; QRF1; 12CC4; hFKH1B; HSPC215  
NCBI Protein Information:forkhead box protein P1
UniProt Protein Name:Forkhead box protein P1
UniProt Synonym Protein Names:Mac-1-regulated forkhead
Protein Family:Forkhead box protein
UniProt Gene Name:FOXP1  
Anti-FOXP1 Antibody (CAB5272)Western blot analysis of extracts of various cell lines, using FOXP1 antibody (CAB5272) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 50s.
Anti-FOXP1 Antibody (CAB5272)Immunofluorescence analysis of U2OS cells using FOXP1 antibody (CAB5272). Blue: DAPI for nuclear staining.

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