Frunevetmab Antibody is a research-grade biosimilar monoclonal antibody targeting Nerve Growth Factor beta subunit. It is a felinized IgG1-kappa antibody. Reactivity: Feline. Supplied as a liquid in 0.01M PBS pH 7.4. Applications: ELISA, flow cytometry, functional assays and in vivo research. Endotoxin: < 10 EU/mg. Purity: >95% as determined by SDS-PAGE. For research use only.
Frunevetmab (NV-02) is a felinized anti-nerve growth factor (NGF) monoclonal antibody with a Kd of 20 pM. Frunevetmab can effectively decrease osteoarthritis (OA) pain in cats. • Nerve growth factor β polypeptide (NGFB) genetic variability: association with the methadone dose required for effective maintenance treatment., PMID:21358750 • Synthesis of the biologically active beta-subunit of human nerve growth factor in Escherichia coli., PMID:1537563 • Nerve growth factor translates stress response and subsequent murine abortion via adhesion molecule-dependent pathways., PMID:16371592 • Two thyroid hormone regulated genes, the beta-subunits of nerve growth factor (NGFB) and thyroid stimulating hormone (TSHB), are located less than 310 kb apart in both human and mouse genomes., PMID:2906326 • Nerve growth factor and the physiology of pain: lessons from congenital insensitivity to pain with anhidrosis., PMID:22882139 • A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception., PMID:14976160 • Rare human nerve growth factor-β mutation reveals relationship between C-afferent density and acute pain evaluation., PMID:27146986 • Linkage relationships of the gene for the beta subunit of nerve growth factor (NGFB) with other chromosome 1 marker loci., PMID:4006521 • Nerve growth factor exhibits an antioxidant and an autocrine activity in mouse liver that is modulated by buthionine sulfoximine, arsenic, and acetaminophen., PMID:23472850 • Assignment of the beta-nerve growth factor (NGFB) to bovine chromosome 3 band q23 by in situ hybridization., PMID:9284944
Product Name:
Frunevetmab Antibody
SKU:
GXBS00050
Size:
100 µg, 1 mg
Antibody Type:
Monoclonal Antibody
Target:
Beta-NGF
Isotype:
IgG1-kappa
Host Species:
Feline
Reactivity:
Feline
Applications:
ELISA, FCM, Functional assay, Research in vivo
Synonyms:
NV-02, 1708936-80-4
Recommended Dilutions:
ELISA: 1:2000-1:20000
Purity:
>95% as determined by SDS-PAGE.
Endotoxin Level:
< 10 EU/mg
Formulation:
0.01M PBS pH 7.4.
State of Matter:
Liquid
Regulatory Status:
For research use only. Not suitable for clinical or therapeutic use.
Product Preparation:
Protein A/G purified from cell culture supernatant.
Storage and Handling:
Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
