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GAD2 Rabbit Polyclonal Antibody (CAB0971)

SKU:
CAB0971
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Neuroscience
  • Neuroscience Anti-GAD2 Antibody CAB0971
  • Neuroscience Anti-GAD2 Antibody CAB0971
  • Neuroscience Anti-GAD2 Antibody CAB0971
  • Neuroscience Anti-GAD2 Antibody CAB0971
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:GAD2 Rabbit Polyclonal Antibody
SKU:CAB0971
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 401-585 of human GAD65/GAD2 (NP_001127838.1).
Sequence:PLQC SALL VREE GLMQ NCNQ MHAS YLFQ QDKH YDLS YDTG DKAL QCGR HVDV FKLW LMWR AKGT TGFE AHVD KCLE LAEY LYNI IKNR EGYE MVFD GKPQ HTNV CFWY IPPS LRTL EDNE ERMS RLSK VAPV IKAR MMEY GTTM VSYQ PLGD KVNF FRMV ISNP AATH QDID FLIE EIER LGQD L
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200
Synonyms:GAD65; GAD65/GAD2
Positive Sample:U-87MG,Mouse brain,Rat brain
Conjugate:Unconjugated
Cellular Localization:Cell junction, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Golgi apparatus membrane, Lipid-anchor, Peripheral membrane protein, cytosol, presynaptic cell membrane, synapse.
Calculated MW:65kDa
Observed MW:60kDa

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.

Purification Method:Affinity purification
Gene ID:2572
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of various cell lines, using GAD65/GAD2 antibody (CAB0971) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.

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